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 Gegenereerd op December 23 2025 16:38 PM

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  • [H1] Keep Current with the Latest in Cell Biology Research
  • [H2] Stay up-to-date with your field!
  • [H3] PR Inhibition Stimulates G6PD Expression to Enhance Malignancy in Luminal Breast Cancer\n [Cell Death & Disease] Researchers silenced progesterone receptor expression in the luminal breast cancer cell lines, MCF7 and T47D, which led to accelerated proliferation and pentose phosphate pathway activity with G6PD expression.\n \n Mammary Cell NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n PAK2 Promotes CTC Cluster Formation by Phosphorylating E-Cadherin to Enhance Cell-Cell Adhesion in Breast Cancer\n [Breast Cancer Research] Scientists revealed that PAK2 promotes circulating tumor cell cluster formation and breast cancer metastasis by enhancing E-cadherin-mediated cell-cell adhesion.\n \n Mammary Cell NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Targeting Cell Surface GRP78-CD44v Interaction Suppresses Cell Migration in Triple-Negative Breast Cancer Cells\n [Scientific Reports] Investigators reported that over 70% of TNBC cells express cell surface GRP78 (csGRP78). MDA-MB-231 cells predominantly exhibit a distinct unipolar morphology, with csGRP78 prominently co-localizing with the variant isoform of CD44.\n \n Mammary Cell NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Targeting Secreted PLA Interactions with EGFR and Vimentin to Arrest Prostate Tumor Growth\n [Cell Death & Disease] Scientists highlighted that the secreted phospholipase A2 human group IIA (contributes to prostaste cancer pathology primarily through specific protein-protein interactions.\n \n NewslettersProstate Cell News\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n High-Salt Diet Induces Immune-Independent Re-Differentiation, Metabolic Shut Down, and Cell Cycle Arrest of Melanoma\n [Cell Death & Disease] Investigators showed that a high salt diet inhibits melanoma growth independent of sodium accumulation and immune cells in skin and lung.\n \n Dermal Cell NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Interaction of lncRNA LENT with DHX36 Regulates Translation and Suppresses Autophagy in Melanoma\n [Cell Death & Disease] The authors characterized LINC00520 (LENT) regulated by microphthalmia-associated transcription factor and strongly expressed in melanocytic melanoma cells. LENT is essential for the proliferation and survival of cultured melanocytic melanoma cells and xenograft tumors.\n \n Dermal Cell NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Etoposide Activates CD8 T Cell Anti-Tumor Immunity in Osteosarcoma through MHC I Upregulation via Tumor-Secreted IL-33 Mediated Signaling\n [Journal for Immunotherapy of Cancer] Scientists revealed the molecular mechanism underlying etoposide-activated CD8+ T cell anti-tumor immunity. The combination of etoposide and anti-PD-1 antibody has the potential to benefit patients with advanced osteosarcoma.\n \n Mesenchymal Cell NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Characterisation of Human Pancreatic Mesenchymal Stromal Cells in Type 1 Diabetes\n [Diabetologia] The authors determined the number, density and islet-protective phenotype of pancreatic MSCs in situ in individuals with and without type 1 diabetes.\n \n Mesenchymal Cell NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Next-Generation CAR-T Cells Design: Leveraging Tumor Features for Enhanced Efficacy\n [Molecular Cancer] The authors discuss the combinatorial approaches aimed at improving antigen recognition, functional adaptability, and antitumor response, thereby expanding the therapeutic impact of CAR-T cells in solid-tumor settings.\n \n Human Immunology NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal-Associated Invariant T (MAIT) Cell Function\n [Immunology] Scientists highlight the critical roles of STAT1, STAT3, STAT5 and HIF1\u03b1 in regulating mucosal-Associated Invariant T (MAIT) cell effector functions.\n \n Human Immunology NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Type I and II Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T-Cell Enhancement in Immunocompetent HLA-Transgenic Mice\n [Allergy] Scientists highlight the distinct roles of IFN-\u03b1 and IFN-\u03b3 in modulating an immune response against abacavir (APC), with IFN-\u03b3 increasing APC activity and IFN-\u03b1 impairing Treg-mediated regulation in immune competent mice.\n \n Immune Regulation NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n The LRRK2 P1446L Mutation Triggers Dopaminergic Neurodegeneration via DAPK1-Mediated Microglial Neuroinflammation and Neuronal Apoptosis\n [NPJ Parkinson'S Disease] Researchers designed LRRK2-P1446L mutant mice and demonstrated that the novel LRRK2-P1446L mutation drives neurodegeneration through death-associated protein kinase 1 (DAPK1) dysregulation.\n \n Neural Cell NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n ","td_block_id":"tdi_80","td_hide_prev":true,"td_hide_next":false})); tmpObj = JSON.parse(JSON.stringify(block_tdi_80)); tmpObj.is_ajax_running = true; tmpObj.td_current_page = 1; tmpObj.td_filter_value = 692; var currentBlockObjSignature = JSON.stringify(tmpObj); tdLocalCache.set(currentBlockObjSignature, JSON.stringify({"td_data":"\n \n \n \n \n \n PR Inhibition Stimulates G6PD Expression to Enhance Malignancy in Luminal Breast Cancer\n [Cell Death & Disease] Researchers silenced progesterone receptor expression in the luminal breast cancer cell lines, MCF7 and T47D, which led to accelerated proliferation and pentose phosphate pathway activity with G6PD expression.\n \n Mammary Cell NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n PAK2 Promotes CTC Cluster Formation by Phosphorylating E-Cadherin to Enhance Cell-Cell Adhesion in Breast Cancer\n [Breast Cancer Research] Scientists revealed that PAK2 promotes circulating tumor cell cluster formation and breast cancer metastasis by enhancing E-cadherin-mediated cell-cell adhesion.\n \n Mammary Cell NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Targeting Cell Surface GRP78-CD44v Interaction Suppresses Cell Migration in Triple-Negative Breast Cancer Cells\n [Scientific Reports] Investigators reported that over 70% of TNBC cells express cell surface GRP78 (csGRP78). MDA-MB-231 cells predominantly exhibit a distinct unipolar morphology, with csGRP78 prominently co-localizing with the variant isoform of CD44.\n \n Mammary Cell NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Targeting Secreted PLA Interactions with EGFR and Vimentin to Arrest Prostate Tumor Growth\n [Cell Death & Disease] Scientists highlighted that the secreted phospholipase A2 human group IIA (contributes to prostaste cancer pathology primarily through specific protein-protein interactions.\n \n NewslettersProstate Cell News\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n High-Salt Diet Induces Immune-Independent Re-Differentiation, Metabolic Shut Down, and Cell Cycle Arrest of Melanoma\n [Cell Death & Disease] Investigators showed that a high salt diet inhibits melanoma growth independent of sodium accumulation and immune cells in skin and lung.\n \n Dermal Cell NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Interaction of lncRNA LENT with DHX36 Regulates Translation and Suppresses Autophagy in Melanoma\n [Cell Death & Disease] The authors characterized LINC00520 (LENT) regulated by microphthalmia-associated transcription factor and strongly expressed in melanocytic melanoma cells. LENT is essential for the proliferation and survival of cultured melanocytic melanoma cells and xenograft tumors.\n \n Dermal Cell NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Etoposide Activates CD8 T Cell Anti-Tumor Immunity in Osteosarcoma through MHC I Upregulation via Tumor-Secreted IL-33 Mediated Signaling\n [Journal for Immunotherapy of Cancer] Scientists revealed the molecular mechanism underlying etoposide-activated CD8+ T cell anti-tumor immunity. The combination of etoposide and anti-PD-1 antibody has the potential to benefit patients with advanced osteosarcoma.\n \n Mesenchymal Cell NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Characterisation of Human Pancreatic Mesenchymal Stromal Cells in Type 1 Diabetes\n [Diabetologia] The authors determined the number, density and islet-protective phenotype of pancreatic MSCs in situ in individuals with and without type 1 diabetes.\n \n Mesenchymal Cell NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal-Associated Invariant T (MAIT) Cell Function\n [Immunology] Scientists highlight the critical roles of STAT1, STAT3, STAT5 and HIF1\u03b1 in regulating mucosal-Associated Invariant T (MAIT) cell effector functions.\n \n Human Immunology NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Type I and II Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T-Cell Enhancement in Immunocompetent HLA-Transgenic Mice\n [Allergy] Scientists highlight the distinct roles of IFN-\u03b1 and IFN-\u03b3 in modulating an immune response against abacavir (APC), with IFN-\u03b3 increasing APC activity and IFN-\u03b1 impairing Treg-mediated regulation in immune competent mice.\n \n Immune Regulation NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n The LRRK2 P1446L Mutation Triggers Dopaminergic Neurodegeneration via DAPK1-Mediated Microglial Neuroinflammation and Neuronal Apoptosis\n [NPJ Parkinson'S Disease] Researchers designed LRRK2-P1446L mutant mice and demonstrated that the novel LRRK2-P1446L mutation drives neurodegeneration through death-associated protein kinase 1 (DAPK1) dysregulation.\n \n Neural Cell NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Multicellular Force Coordination Constructs Microchannel Networks for Barrier-Free Metastasis across Extracellular Matrix\n [Science Advances] Researchers revealed that cancer cells collaboratively reprogram ECM to construct interconnected microchannel networks functioning as \u201csuperhighways\u201d for barrier-free metastasis.\n \n Extracellular Matrix NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n ","td_block_id":"tdi_80","td_hide_prev":true,"td_hide_next":false})); tmpObj = JSON.parse(JSON.stringify(block_tdi_80)); tmpObj.is_ajax_running = true; tmpObj.td_current_page = 1; tmpObj.td_filter_value = 693; var currentBlockObjSignature = JSON.stringify(tmpObj); tdLocalCache.set(currentBlockObjSignature, JSON.stringify({"td_data":"\n \n \n \n \n \n Next-Generation CAR-T Cells Design: Leveraging Tumor Features for Enhanced Efficacy\n [Molecular Cancer] The authors discuss the combinatorial approaches aimed at improving antigen recognition, functional adaptability, and antitumor response, thereby expanding the therapeutic impact of CAR-T cells in solid-tumor settings.\n \n Human Immunology NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n CRISPR Screens in Human Neural Organoids and Assembloids\n [Nature Protocols] Scientists presented a protocol that combines pooled CRISPR\u2013Cas9 screening with neural organoid and assembloid models and illustrate how it can be applied to map hundreds of disease genes onto cellular pathways and specific aspects of human neural development.\n \n Neural Cell NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Emerging Trends in Gene and Cell Therapy: CRISPR in DNA Editing and beyond\n [Cell Reports Medicine] The authors highlight how advances in genome editing technologies, ranging from CRISPR-Cas nucleases to base and prime editors, are expanding the therapeutic landscape beyond traditional gene knockout approaches.\n \n Cell Therapy NewsNewsletters\n \n December 22, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Comparative \u03b2-Cell Development: Insights from Rodents, Humans, and Induced Pluripotent Stem Cell Models\n [Stem Cell Research & Therapy] Stepwise pancreatic \u03b2-cell differentiation protocols, designed to recapitulate key developmental milestones of pancreatic organogenesis\u2014from definitive endoderm to mature, glucose-responsive \u03b2-cells\u2014draw on insights from both rodent and human developmental biology.\n \n NewslettersPancreatic Cell News\n \n December 19, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Regulation of T Cell Exhaustion and Stemness: Molecular Mechanisms and Implications for Cancer Immunotherapy\n [Cellular & Molecular Immunology] The authors summarize recent advances in understanding the molecular mechanisms controlling the exhaustion and stemness of T cells and explores the potential of rewiring these circuits to increase the efficiency of T-cell-based immunotherapy.\n \n Human Immunology NewsNewsletters\n \n December 19, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Bringing Natural Killer Cells to the Clinic: Opportunities Beyond Cancer\n [Journal of Experimental Medicine] The biology of NK cells has been exploited in innovative cancer immunotherapies, leading to clinical advances including allogeneic NK cell infusions, chimeric antigen receptor NK cells, and NK cell engager technologies.\n \n Human Immunology NewsNewsletters\n \n December 19, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Immune Cell Regulation of Zebrafish Heart Regeneration\n [Arteriosclerosis Thrombosis and Vascular Biology] The authors review the distinct contributions of neutrophils, macrophages, and lymphoid cells during zebrafish heart regeneration, with a focus on their temporal coordination and regulatory signaling pathways.\n \n Immune Regulation NewsNewsletters\n \n December 19, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Cancer-Associated Fibroblasts in the Tumor Microenvironment: Heterogeneity, Crosstalk Mechanisms, and Therapeutic Implications\n [Molecular Cancer] The authors discuss recent advancements in our understanding of the heterogeneity of cancer-associated fibroblasts (CAFs), elucidate their multifaceted interactions within the TME, and explore novel therapeutic strategies targeting CAFs across various cancer types.\n \n Extracellular Matrix NewsNewsletters\n \n December 19, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n EGLN1 (PHD2) Role in Tumor Microenvironment: Insights for Therapeutic Targeting\n [Experimental & Molecular Medicine] Scientists explore the role of this protein in some of the key components of the TME, focusing on the functions of EGLN1\/PHD2 in endothelial, stromal and immune cells.\n \n Extracellular Matrix NewsNewsletters\n \n December 19, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Unveiling Hidden Players: The Role of Intratumoral Microbiota in Gastrointestinal Cancer Dynamics\n [Journal of Cancer Research and Clinical Oncology] The authors summarize key developments in understanding the role of the intratumoral microbiota in gastrointestinal cancers and discusses future directions for translating these insights into clinical applications.\n \n Intestinal Cell NewsNewsletters\n \n December 19, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n HER2 Expression in Breast Cancer: Evidence Gaps and Challenges\n [NPJ Precision Oncology] The authors review the emerging HER2-Low and Ultralow breast cancer subtypes, and evaluate the distinct therapeutic responses across the spectrum of HER2 expression in different breast cancer subtypes.\n \n Mammary Cell NewsNewsletters\n \n December 18, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Emerging Strategies for Targeting Vasculogenic Mimicry in Breast Cancer Treatment\n [Discover Oncology] The intricate molecular mechanisms involved in vasculogenic mimicry within breast cancer present considerable challenges to the development of effective therapeutic strategies.\n \n Mammary Cell NewsNewsletters\n \n December 18, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n ","td_block_id":"tdi_80","td_hide_prev":true,"td_hide_next":false})); tmpObj = JSON.parse(JSON.stringify(block_tdi_80)); tmpObj.is_ajax_running = true; tmpObj.td_current_page = 1; tmpObj.td_filter_value = 783; var currentBlockObjSignature = JSON.stringify(tmpObj); tdLocalCache.set(currentBlockObjSignature, JSON.stringify({"td_data":"\n \n \n \n \n \n 73 Million SEK from the Swedish Cancer Society to MEB Researchers\n [Karolinska Institute] The Swedish Cancer Society has announced its research grants for 2025. Around 73 million has been awarded to researchers at the Department of Medical Epidemiology and Biostatistics at Karolinska Institute.\n \n NewslettersProstate Cell News\n \n December 19, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Research to Catch Prostate Cancer Earlier Gets Grant\n [Otago Daily Times] University of Otago pathology and molecular medicine researcher Dr. Jim Smith has received a Health Research Council grant to create a targeted DNA methylation-based blood test to detect prostate cancer earlier.\n \n NewslettersProstate Cell News\n \n December 19, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Shilpa S. Murthy Receives 1.1 Million DoD Career Development Award\n [Yale School of Medicine] Dr. Shilpa Murthy has been awarded a prestigious $1.1 million Career Development Award from the Department of Defense (DoD).\n \n Intestinal Cell NewsNewsletters\n \n December 19, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Austrian Science Fund (FWF) Supports Two IMBA Research Projects\n [Institute of Molecular Biotechnology (IMBA)] The FWF has awarded two grants to IMBA scientists. The projects, led by J\u00fcrgen Knoblich and Nicolas Rivron, will use stem cell-based models to advance our knowledge of cell transplantation therapies and human implantation, respectively.\n \n NewslettersOrganoid News\n \n December 18, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Athira Pharma Announces Exclusive License to Lasofoxifene Phase 3 Development Program for Metastatic Breast Cancer Candidate and a Financing for up to $236 Million\n [Athira Pharma, Inc.] Athira Pharma, Inc. announced that it has entered into an agreement to acquire the rights for the development and commercialization of lasofoxifene, a a selective estrogen receptor modulator, in a potentially registrational Phase III trial for the potential treatment of metastatic breast cancer.\n \n Mammary Cell NewsNewsletters\n \n December 18, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n UT Health San Antonio Awarded $3 Million CPRIT Grant to Bolster Cancer Research and Prevention Efforts in South Texas\n [UT Health San Antonio] UT Health San Antonio received nearly $3 million in new academic and prevention awards as part of the latest, almost $154 million funding round announced by the Cancer Prevention Research Institute of Texas (CPRIT).\n \n Cancer Stem Cell NewsNewsletters\n \n December 17, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Tiziana Life Sciences Doses First Patient in Phase II Alzheimer\u2019s Clinical Trial\n [Tiziana Life Sciences, Ltd. (GlobeNewswire)] Tiziana Life Sciences, Ltd. announced that the first patient has been dosed with intranasal foralumab in its Phase II randomized, placebo-controlled clinical trial in patients with early Alzheimer\u2019s disease.\n \n Neural Cell NewsNewsletters\n \n December 17, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n First Patient in Arizona Treated with New Immune-Cell Therapy at HonorHealth Research Institute\n [HonorHealth Research Institute (EurekAlert)] A patient with synovial sarcoma, a soft-tissue cancer that usually occurs in the large joints of the arms and legs, is the first in Arizona treated with a new immune-cell-therapy known as TECELRA at the HonorHealth Research Institute.\n \n Cell Therapy NewsHuman Immunology NewsMesenchymal Cell NewsNewsletters\n \n December 16, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n FDA Approves Marginal Zone Lymphoma CAR T Cell Treatment\n [Memorial Sloan Kettering Cancer Center] The US FDA has approved a new therapy for marginal zone lymphoma: lisocabtagene maraleucel. The approval is based on results from a Phase II clinical trial led by Memorial Sloan Kettering Cancer Center hematologist-oncologist Dr. Lia Palomba.\n \n Cell Therapy NewsHematopoiesis NewsNewsletters\n \n December 15, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n CAR-T Developers Will Need Randomized Trials as FDA Eyes Tighter Approval Requirements\n [BioSpace] For traditional approval, CAR T therapies will need to establish superiority over current standard treatments, including already-approved CAR T products.\n \n Cell Therapy NewsNewsletters\n \n December 15, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n Phase I Study Advances A9-3408, an Actinium-225-Based Radiotherapeutic, Building on the Progress of the Company\u2019s Imaging Agent, A9-3202, Which Entered the Clinic Last Year\n [Alpha-9 Oncology] Alpha-9 Oncology announced the initiation of dosing in a Phase I study evaluating A9-3408, a novel Actinium-225-based radiotherapeutic targeting melanocortin 1 receptor (MC1R) for the treatment of patients with melanoma.\n \n Dermal Cell NewsNewsletters\n \n December 15, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n \n \n \n \n \n \n ImmuneWalk Therapeutics Announces Positive Results from Phase I SAD\/MAD Study of IW-601, a First-In-Class Therapeutic with Broad Potential in Inflammatory and Autoimmune Diseases\n [ImmuneWalk Therapeutics] ImmuneWalk Therapeutics announced positive results from the POINTGUARD study evaluating subcutaneously administered IW-601, a highly selective biologic inhibitor of myeloid cell tissue infiltration. The study met all primary and secondary endpoints, demonstrating safety and tolerability of IW-601 at all doses.\n \n Immune Regulation NewsNewsletters\n \n December 12, 2025 \n \n \n \n \n \n Read more...\n \n \n \n \n\n ","td_block_id":"tdi_80","td_hide_prev":true,"td_hide_next":false})); Block title
  • [H3] PR Inhibition Stimulates G6PD Expression to Enhance Malignancy in Luminal Breast Cancer
  • [H3] PAK2 Promotes CTC Cluster Formation by Phosphorylating E-Cadherin to Enhance Cell-Cell Adhesion in Breast Cancer
  • [H3] Targeting Cell Surface GRP78-CD44v Interaction Suppresses Cell Migration in Triple-Negative Breast Cancer Cells
  • [H3] Targeting Secreted PLA Interactions with EGFR and Vimentin to Arrest Prostate Tumor Growth
  • [H3] High-Salt Diet Induces Immune-Independent Re-Differentiation, Metabolic Shut Down, and Cell Cycle Arrest of Melanoma
  • [H3] Interaction of lncRNA LENT with DHX36 Regulates Translation and Suppresses Autophagy in Melanoma
  • [H3] Etoposide Activates CD8 T Cell Anti-Tumor Immunity in Osteosarcoma through MHC I Upregulation via Tumor-Secreted IL-33 Mediated Signaling
  • [H3] Characterisation of Human Pancreatic Mesenchymal Stromal Cells in Type 1 Diabetes
  • [H3] Next-Generation CAR-T Cells Design: Leveraging Tumor Features for Enhanced Efficacy
  • [H3] Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal-Associated Invariant T (MAIT) Cell Function
  • [H3] Type I and II Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T-Cell Enhancement in Immunocompetent HLA-Transgenic Mice
  • [H3] The LRRK2 P1446L Mutation Triggers Dopaminergic Neurodegeneration via DAPK1-Mediated Microglial Neuroinflammation and Neuronal Apoptosis

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